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Search
Searches can be performed at either the disease level for retrieving a list of genes deregulated in a disease, or at the gene level for identifying diseases that the gene of interest is abnormally expressed. To perform a disease-centric search, select a disease from the drop-down menu that displays the disease names. The output report includes a list of genes that are differentially expressed between the normal and the disease samples with predefined statistical significance. The default adjusted P value or false discovery rate is set to 0.1 and can be changed by users. Smaller p values indicate higher statistical significance and therefore result in less number of genes in the output. Included in the output table are columns of Entrez Gene ID, gene symbol, gene description, average expression values in the normal and disease samples, the adjusted P values, fold change in the disease group vs. the normal group. Gene expression values are normalized such that a numerical value of 200 is estimated to represent 3-5 copies of mRNA molecules per cell. Many of these columns can be further linked to more detailed information. Fold change values are linked to a box plot showing the distribution of individual expression values in the normal and the disease groups. Entrez Gene IDs are used to link the output of a search to Entrez Gene page at NCBI and KEGG pathway databases. A gene centric search generates an output table including the analysis results for all of the disease datasets in the DGEM database. Similarly, the output provides information such as average expression values in the normal and disease samples, the adjusted P values, fold change in the disease group vs. the normal group, and links to the OMIM page at NCBI for each disease. A gene centric search generates an output table including the analysis results for all of the disease datasets in the DGEM database. Similarly, the output provides information such as average expression values in the normal and disease samples, the adjusted P values, fold change in the disease group vs. the normal group, and links to the OMIM page at NCBI for each disease.

Submission
The submission form is designed for scientific community to share their array data on primary human disease samples. The submitter's name, email address, a brief text description of the project and uploading the data are sufficient. The submission process is simple enough not to discourage potential contributors. A confirmation email will be sent to the submitter upon successful data transmission. The user submitted data will be manually reviewed, followed by statistical analysis before they are entered into the DGEM database.